*, co-first;  †, corresponding author

91. York, A.G.†, Skadow, M.H., Oh, J., Qu, R., Zhou, Q.D, Hsieh, W.-Y., Mowel, W.K., Brewer, J.R., Kaffe, E., Williams, K.J., Kluger, Y., Smale, S.T., Crawford, J.M., Bensinger, S.J.†, Flavell, R.A.† 2024. IL-10 constrains sphingolipid metabolism to limit inflammation. Nature  

90. Ontai-Brenning, A., Hamchand, R., Crawford, J.M., Goodman, A.L.† 2023. Gut microbes modulate (p)ppGpp during a time-restricted feeding regimen. mBio. e01907-23. 

89. Combs, J., Wright, T., Chen, L., Holmes, R., Qin, B., Oh, J., Crawford, J.M., Herzon, S.B.† 2023. Enantioselective synthesis of anhydrogukulenin A C2-acetate. ChemRxiv.

88. Huseman, E., Lo, A., Fedorova, O., Elia, J., Gueble, S., Lin, K., Sundaram, R., Burgenske, D., Oh, J., Liu, J., Menges, F., Rees, M., Ronan, M., Roth, J., Batista, V., Crawford, J.M., Sarkaria, J., Pyle, A., Bindra, R.†, Herzon, S.B.† 2023. Mechanism of Action of KL-50, a Novel Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers. ChemRxiv.

87. Urdaneta-Paez, V., Hamchand, R., Anthony, K., Crawford, J.M., Sutherland, A.G., Kazmierczak, B.I.† 2023. Identification of efflux substrates using a riboswitch-based reporter in Pseudomonas aeruginosa. mSphere. e0006923. 

86. Cao, Y., Oh, J., Xue, M., Huh, W.J., Wang, J., Gonzalez-Hernandez, J.A., Rice, T.A., Martin, A.L., Song, D., Crawford, J.M., Herzon, S.B., Palm, N.W.† 2022. Commensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites. Science. 378(6618):  DOI: 10.1126/science.abm3233. 

85. Gatsios, A.*, Kim, C.S.*, York, A., Flavell, R.A., Crawford, J.M.† 2022. Cellular stress-induced metabolites in Escherichia coli. J. Nat. Prod. 85(11): 2626-2640. 

84. Cho, W., York, A.G., Wang, R., Wyche, T.P., Piizzi, G., Flavell, R.A., Crawford, J.M.† 2022. N-acyl-amides from Neisseria meningitidis and their role in sphingosine receptor signaling. ChemBioChem. 23(22): e202200490. 

83. Wei, Z., Oh, J., Flavell, R.A.†, Crawford, J.M.† 2022. LACC1 bridges NOS2 and polyamine metabolism in inflammatory macrophages. Nature. 609: 348-353. 

82. Ding, C.*, Xu, H.*, Yu, Z.*, Roulis, M., Qu, R., Zhou, J., Oh, J., Crawford, J.M., Gao, Y., Jackson, R., Sefik, E., Li, S., Wei, Z., Skadow, M., Yin, Z., Ouyang, X., Wang, L., Zou, Q., Su, B., Hu, W.†, Flavell, R.A.†, Li, H.-B.† 2022. RNA m6A demethylase ALKBH5 regulates the development of gamma-delta T cells. Proc. Natl. Acad. Sci. USA. 119(33): e2203318119. 

81. Wiemann, J.†, Menendez, I., Crawford, J.M., Fabbri, M., Gauthier, J.A., Hull, P.M., Norell, M.A., Briggs, D.E.G. 2022. Fossil biomolecules reveal an avian metabolism in the ancestral dinosaur. Nature. 606: 522-526. 

80. Patel, J.R.*, Oh, J.*, Wang, S., Crawford, J.M., Isaacs, F.J. 2022. Cross-kingdom expression of synthetic genetic elements promotes discovery of metabolites in the human microbiome. Cell. 185(9): 1487-1505.  

79. Li, J.-H., Cho, W., Hamchand, R., Oh, J., Crawford, J.M. 2021. A conserved nonribosomal peptide synthetase in Xenorhabdus bovienii produces citrulline-functionalized lipopeptides. J. Nat. Prod. 84(10): 2692-2699.  

78. Kim, C.S.†, Turocy, T., Moon, G., Shine, E.E., Crawford, J.M.† 2021. Escherichia coli-derived gamma-lactams and structurally related metabolites are produced at the intersection of colibactin and fatty acid biosynthesis. Org. Lett. 23(17): 6895-6899. 

77. Crawford, J.M.†, Tang, G.-L.†, Herzon, S.B.† 2021. Natural Products: An Era of Discovery in Organic Chemistry. J. Org. Chem. 86(16): 10943-10945. 

76. Gatsios, A., Kim, C.S., Crawford, J.M.† 2021. Escherichia coli small molecule metabolism at the host-microorganism interface. Nature Chem Bio. 17(10): 1016-1026.  

75. Schorn M.A.*, Verhoeven S.*, Ridder L, Huber F, Acharya DD, Aksenov AA, Aleti G, Moghaddam JA, Aron AT, Aziz S, Bauermeister A, Bauman KD, Baunach M, Beemelmanns C, Beman JM, Berlanga-Clavero MV, Blacutt AA, Bode HB, Boullie A, Brejnrod A, Bugni TS, Calteau A, Cao L, Carrión VJ, Castelo-Branco R, Chanana S, Chase AB, Chevrette MG, Costa-Lotufo LV, Crawford JM, Currie CR, Cuypers B, Dang T, de Rond T, Demko AM, Dittmann E, Du C, Drozd C, Dujardin JC, Dutton RJ, Edlund A, Fewer DP, Garg N, Gauglitz JM, Gentry EC, Gerwick L, Glukhov E, Gross H, Gugger M, Guillén Matus DG, Helfrich EJN, Hempel BF, Hur JS, Iorio M, Jensen PR, Kang KB, Kaysser L, Kelleher NL, Kim CS, Kim KH, Koester I, König GM, Leao T, Lee SR, Lee YY, Li X, Little JC, Maloney KN, Männle D, Martin H C, McAvoy AC, Metcalf WW, Mohimani H, Molina-Santiago C, Moore BS, Mullowney MW, Muskat M, Nothias LF, O’Neill EC, Parkinson EI, Petras D, Piel J, Pierce EC, Pires K, Reher R, Romero D, Roper MC, Rust M, Saad H, Saenz C, Sanchez LM, Sørensen SJ, Sosio M, Süssmuth RD, Sweeney D, Tahlan K, Thomson RJ, Tobias NJ, Trindade-Silva AE, van Wezel GP, Wang M, Weldon KC, Zhang F, Ziemert N, Duncan KR, Crüsemann M, Rogers S, Dorrestein P.C., Medema M.H., van der Hooft J.J.J. 2021. A community resource for paired genomic and metabolomic data mining. Nature Chem Bio. 17(4): 363-368.

74. Shine, E.E., Crawford, J.M.† 2021. Molecules from the Microbiome.  Annual Rev Biochem. 90: 789-815. 

73. Turocy, T., Crawford, J.M.† 2020. Dual targeting of v-ATPase and mTORC1 signaling disarms multidrug-resistant cancers. Cell Chem Bio. 27(11): 1329-1331.  

72. Li, J.-H.*, Oh, J.*, Kienesberger, S., Kim, N.Y., Clarke, D.J., Zechner, E.L., Crawford, J.M.† 2020. Making and breaking leupeptin protease inhibitors in pathogenic gammaproteobacteria. Angew. Chem. Int. Ed. 59(41): 17872-17880. 

     Selected as “Hot Paper.” 

71. Park, H.B.*, Wei, Z.*, Oh, J., Xu, H., Kim, C.S., Wang, R., Wyche, T.P., Piizzi, G., Flavell, R.A.†, Crawford, J.M.† 2020. Sulfamethoxazole drug stress upregulates antioxidant immunomodulatory metabolites in Escherichia coli. Nature Micro.  5: 1319-1329. 

     See the nice News & Views:  Alexander, M., Turnbaugh, P.J. 2020. Microbiome: Stressed-out gut bacteria are pterin up gut inflammation. Nature Micro. 5: 1316-1318. 

70. Wernke, K.M., Xue, M., Tirla, A., Kim, C.S., Crawford, J.M., Herzon, S.B.† 2020. Structure and bioactivity of colibactin.  Bioorg. Med. Chem. Lett. 30(15): 127280.  

69. Goddard, T.N., Patel, J., Park, H.B., Crawford, J.M.† 2020. Dimeric stilbene antibiotics target the bacterial cell wall in drug-resistant Gram-positive pathogens. Biochemistry. 59(21): 1966-1971.  

68. Wiemann, J.†, Crawford, J.M., Briggs, D.E.G. 2020. Phylogenetic and physiological signals in metazoan fossil biomolecules. Science Advances. 6(28): eaba6883.

     See also the nice follow up work: Wiemann, J., Briggs, D.E.G. 2021. Validation of biosignatures confirms the informative nature of fossil organic Raman spectra. 

67. Adaku, N.*, Park, H.B.*, Spakowicz, D.J., Tiwari, M.K., Strobel, S.A., Crawford, J.M.†, Rogers, F.A.† 2020. A novel DNA repair inhibitor isolated from an Ecuadorian fungal endophyte exhibits synthetic lethality in PTEN-deficient glioblastoma. J. Nat. Prod. 83(6): 1899-1908.   

66. Park, H.B.*, Goddard, T.N.*, Oh, J., Patel, J., Wei, Z., Perez, C.E., Mercado, B.Q., Wang, R., Wyche, T.P., Piizzi, G., Flavell, R.A., Crawford, J.M.† 2020. Bacterial autoimmune drug metabolism transforms an immunomodulator into structurally and functionally divergent antibiotics. Angew. Chem. Int. Ed.  59(20): 7871-7880. 

     Selected as Hot Paper among the VIP articles. 

65. Kim, C.S.*, Li, J.-H.*, Barco, B., Park, H.B., Gatsios, A., Damania, A., Wang, R., Wyce, T.P., Piizzi, G., Clay, N.K., Crawford, J.M.† 2020. Cellular stress upregulates indole signaling metabolites in Escherichia coli.  Cell Chem Bio. 27(6): 698-707.  

64. Keiichiro, T.†, Prendergast, A., Hintzen, J., Kumar, A., Chung, M., Koleske, A., Crawford, J.M., Nicoli, S., Schwartz, M.A.† 2020. Latrophilins are essential for endothelial junctional fluid shear stress mechanotransduction. BioRxiv.

63. Kim, C.S., Gatsios, A., Cuesta, S., Lam, Y.C., Wei, Z., Chen, H., Russell, R.M., Shine, E.E., Wang, R., Wyche, T.P., Piizzi, G., Flavell, R.A., Palm, N.W., Sperandio, V., Crawford, J.M.† 2020. Characterization of autoinducer-3 structure and biosynthesis in E. coli. ACS Central Science.  6(2): 197-206.  

     See the very nice ACS Central Science commentary from Herman Sintim’s lab. See also Yale West Campus News, Phys Org News, and Health Canal

62. Yang, J.*, Schleicher, T.R.*, Dong, Y., Park, H.B., Lan, J., Cresswell, P., Crawford, J.M., Dimopoulos, G.†, Fikrig, E.† 2020. Disruption of mosGILT in Anopheles gambiae impairs ovarian development and Plasmodium infection. J. Exp. Med. 217(1) pii: e20190682.  

61. Oh, J., Kim, N.Y., Chen, H., Palm, N.W., Crawford, J.M.† 2019. An Ugi-like biosynthetic pathway encodes bombesin receptor sub-type-3 agonists. J. Am. Chem. Soc. 141(41): 16271-78.

60. Park, H.B., Lam, Y.C., Gaffney, J.P., Weaver, J.C., Krivoshik, S.R., Hamchand, R., Pieribone, V., Gruber, D.F.†, Crawford, J.M.† 2019. Bright-green biofluorescence in sharks derives from bromo-kynurenine metabolism. iScience. 19: 1291-1336. 

     See the associated news articles: CNNNew York TimesNational GeographicPBSScienceScience DailyNews WeekCosmos MagazineEarthArs TechnicaInside ScienceThe GaurdianABC News, New ScientistScience AlertChemistry & Engineering NewsYahoo FinanceBBC News, Forbes, Chemistry World, and many others.

59. Shine, E.E., Nwe, P.-K., Crawford, J.M.† 2019. Chemistry and Enzymology Encoded by the Human Microbiome. Comprehensive Natural Products III: Chemistry and Biology. Cite Book Chapter as:  Jason Crawford, Chemistry and Enzymology Encoded by the Human Microbiome, 2020. In: Hung-Wen (Ben) Liu and Tadhg P. Begley (eds.) Comprehensive Natural Products III: Chemistry and Biology, vol.[4], pp. 261-286. UK: Elsevier. 

58. Kim, N.Y., Goddard, T.N., Sohn, S., Spiegel, D.A., Crawford, J.M.† 2019. Biocatalytic reversal of advanced glycation end product modification. ChemBioChem. 20(18): 2402-10.   

57. Wei, Z., Crawford, J.M.† 2019. The gut microbiome says NO to microRNA-mediated gene silencing. Biochemistry. 58(16): 2089-90.  

56. Chen, H., Nwe, P.-K., Rosen, C.E., Kuchroo, M., Cline, G., Kruse, A.C., Ring, A.M., Crawford, J.M., Palm, N.W.† 2019. A forward chemical genetic screen reveals gut microbiota metabolites that modulate host physiology. Cell. 177(5): 1217-31. 

     See the associated news coverage: Cell Host & Microbe, Precision Clinical MedicineYale News, and Science Bulletin.

55. Xue, M.*, Kim, C.S.*, Healy, A.R., Wernke, K.M., Wang, Z., Frischling, M.C., Shine, E.E., Wang, W., Herzon, S.B.†, Crawford, J.M.† 2019. Structure elucidation of colibactin and its DNA crosslinks. Science. 365(6457): eaax2685.     

     See the associated news articles: Chemical & Engineering NewsYale News, and Nature Chem Bio

54. Healy, A.R., Wernke, K.M., Kim, C.S., Lees, N.R., Crawford, J.M.†, Herzon, S.B.† 2019. Synthesis and reactivity of precolibactin 886. Nature Chemistry. 11(10): 890-8. 

53. Perez, C.E., Crawford, J.M.† 2018. Characterization of a hybrid nonribosomal peptide-carbohydrate biosynthetic pathway in Photorhabdus luminescens. Biochemistry. 58(8): 1131-1140. 

52. Lozano, G.L., Park, H.B., Bravo, J.I., Armstrong, E.A., Denu, J.M., Stabb, E.V., Broderick, N.A., Crawford, J.M.†, Handelsman, J.† 2019. Bacterial analogs of plant tetrahydropyridine alkaloids mediate microbial interactions in a rhizosphere model system. AEM. pii: AEM.03058-18. 

51. Lozano, G.L., Bravo, J.I., Garavito, M.F., Park, H.B., Hurley, A., Peterson, S.B., Stabb, E.V., Crawford, J.M., Broderick, N.A., Handelsman, J.† 2019. Introducing THOR, a model microbiome for genetic dissection of community behavior. mBio. 10(2). pii: e02846-18. 

50. Xue, M., Shine, E.E., Wang, W., Crawford, J.M.†, Herzon, S.B.† 2018. Characterization of natural colibactin-nucleobase adducts by tandem MS and isotopic labeling. Support for DNA alkylation by cyclopropane ring opening. Biochemistry. 57(45): 6391-94.   

49. Parker, M.T., Gopinath, S., Perez, C.E., Linehan, M.M., Crawford, J.M., Iwasaki, A., Lindenbach, B.D.† 2018. Innate immune priming by cGAS as a preparatory countermeasure against RNA virus infection. BioRxiv 10.1101/434027. 

48. Shine, E.E.*, Xue, M.*, Patel, J.R., Healy, A.R., Surovtseva, Y.V., Herzon, S.B.†, Crawford, J.M.† 2018. Model colibactins exhibit human cell genotoxicity in the absence of host bacteria. ACS Chem Bio. 13(12): 3286-93.  

47. Tessler, M.†, Gaffney, J.P.†, Crawford, J.M., Trautman, E., Gujarati, N.A., Alatalo, P., Pieribone, V.A., Gruber, D.F.  2018. Luciferin production and luciferase transcription in the bioluminescent copepod Metridia lucens. PeerJ. 6: e5506. 

46. Oh, J., Patel, J., Park, H.B., Crawford, J.M.† 2018. Beta-lactam biotransformations activate innate immunity. J. Org. Chem. 83(13): 7173-7179.  

45. Lam, Y.C., Crawford, J.M.† 2018.  Antimicrobials: Discovering Antibiotics from the Global Microbiome. Nature Micro. 3: 392-393.  

44. Patel, J., Crawford, J.M.† 2018. Microbiota-regulated outcomes of human cancer immunotherapy via the PD-1/PD-L1 axis. Biochemistry. 57(6): 901-903. 

43. Triparthi, P.*, Shine, E.E.*, Healy, A.R., Kim, C.S., Herzon, S.B., Bruner, S.D.†, Crawford, J.M.† 2017. ClbS is a cyclopropane hydrolase that confers colibactin resistance. J. Am. Chem. Soc. 139(49): 17719-17722. 

     Research Highlights: Deane, C. 2017. Resistance Mechanisms: Watering down a warhead. Nature Chem. Bio. 14(1): 1.  JACS Spotlight: Lockwood, D. 2017. Decoding the bullet proof vest of bacteria linked with colorectal cancer. J. Am. Chem. Soc. 139(50): 18123. 

42. Perez, C.E., Park, H.B., Crawford, J.M.† 2018. Functional characterization of a condensation domain from a pteridine-nonribosomal peptide hybrid pathway in Photorhabdus luminescens. Biochemistry. 57(3): 354-361.  

41. Trautman, E.P., Crawford, J.M.† 2017.  A New Nucleoside Antibiotic Chokes Bacterial RNA polymerase. Biochemistry. 56: 4923-4924. 

40. Guntaka, N.S., Healy, A.R., Crawford, J.M., Herzon, S.B., Bruner, S.D.† 2017.  Structure and Functional Analysis of ClbQ, an Unusual Intermediate-Releasing Thioesterase from the Colibactin Biosynthetic Pathway. ACS Chem. Bio. 12(10): 2598-2608.   

39. Park, H.B.*, Perez, C.E.*, Barber, K., Rinehart, J., Crawford, J.M.† 2017. Genome mining unearths a hybrid nonribosomal peptide synthetase-like-pteridine synthase biosynthetic gene cluster. eLife. 6: e25229. 

     See Yale West Campus News. Atherton, J. 2017. New molecules unearthed for future medical discovery. March 31.

38. Park, H.B., Sampathkumar, P., Perez, C.E., Lee, J.H., Tran, J., Bonanno, J.B., Hallem, E.A., Almo, S.C., Crawford, J.M.† 2017. Stilbene epoxidation and detoxification in a Photorhabdus luminescens-nematode symbiosis. J. Biol. Chem. 292(16): 6680-6694. 

37. Trautman, E.P., Healy, A.R., Shine, E.E., Herzon, S.B., Crawford, J.M.† 2017. Domain-targeted metabolomics delineates the heterocycle assembly steps of colibactin biosynthesis. J. Am. Chem. Soc. 139(11): 4195-4201.   

     Selected as JACS Spotlight. Lockwood, D. 2017. Drilling down into multidomain enzymes to image small-molecule synthesis. J. Am. Chem. Soc. 139(13): 4583. 

36. Torring, T., Shames, S.R., Cho, W., Roy, C.R., Crawford, J.M.† 2017. Acyl-histidines: New N-acyl-amides from Legionella pneumophila. ChemBioChem. 18(7): 638-646.

35. Fischer, C.N., Trautman, E.P., Crawford, J.M., Stabb, E.V., Handelsman, J., Broderick, N.A.† 2017. Metabolite exchange between microbiome members produces compounds that influence Drosophila behavior. eLife. 6: e18855.  

34. Healy, A.R., Nikolayevskiy, H., Patel, J., Crawford, J.M., Herzon, S.B.† 2016.  A mechanistic model for colibactin-induced genotoxicity. J. Am. Chem. Soc. 138 (48): 15563-15570.

33. Park, H.B., Perez, C.E., Perry, E.K., Crawford, J.M.† 2016. Activating and attenuating the amicoumacin antibiotics. Molecules. 21(7): 824. 

32. Park, H.B., Crawford, J.M.† 2016. Pyrazinone protease inhibitor metabolites from Photorhabdus luminescens. J. Antibiot. 69(8): 616-621.  

31. Healy, A.R., Vizcaino, M.I., Crawford, J.M., Herzon, S.B. 2016. Convergent and modular synthesis of candidate precolibactins. Structural revision of precolibactin A. J. Am. Chem. Soc. 138(16): 5426-5432. 

30.​ Trautman, E., Crawford, J.M.† 2016. Linking biosynthetic gene clusters to their metabolites via pathway-targeted molecular networking. Curr. Topic. Med. Chem. 16(15): 1705-1716.

29. Vizcaino, M.I., Crawford, J.M.† 2016. Secondary metabolic pathway-targeted metabolomicsMeth. Mol. Biol. 1401: 175-195.  

28. Park, H.B., Crawford, J.M.† 2015. Lumiquinone A: An alpha-aminomalonate-derived aminobenzoquinone from Photorhabdus luminescens. J. Nat. Prod. 78(6): 1437-41. 

27. Vizcaino, M.I., Crawford, J.M.† 2015. The colibactin warhead crosslinks DNA. Nature Chem.7: 411-7. 

     News & Views: Schmidt, E. 2015. Natural Products: Hunting microbial metabolites. Nature Chem. 7:375-6.  F1000: Tang, G.-L. 2015. Excellent Recommendation. Research in the News: Shelton, J. 2015. Spotting a molecular warhead for disease in the human gut. YaleNews. April 6.

26. Engel, P.,† Vizcaino, M.I., Crawford, J.M. 2014. Gut symbionts from distinct hosts exhibit genotoxic activity via divergent colibactin biosynthetic pathways. Appl. Environ. Microbiol.81(4): 1502-12. 

25. Guo, X., Crawford, J.M.† 2014. An atypical carbohydrate-NRPS genomic island encodes a novel lytic transglycosylase. Chem. Biol. 21(10): 1271-7. 

     Research in the News: Shelton, J. 2014. Setting a course for genomic islands. YaleNews. September 15. 

24. Vizcaino, M.I., Engel, P., Trautman, E., Crawford, J.M.† 2014. Comparative metabolomics and structural characterizations illuminate colibactin pathway-dependent small molecules. J. Am. Chem. Soc. 136(26): 9244-7. 

23. Vizcaino, M.I., Guo, X., Crawford, J.M.† 2014. Merging chemical ecology with bacterial genome mining for secondary metabolite discovery. J. Ind. Microbiol. Biotechnol. 41(2): 285-99.

     Special Issue: Invited manuscript to be included in the Special Issue on Microbial Genome Mining dedicated to Sir David Hopwood on the occasion of his 80th birthday. Nature’s Drugs: Allen, J. 2013. The search for organic treatment products. Yale Scientific Magazine. December.

22. Vagstad, A.L., Newman, A.G., Storm, P.A., Belecki, K., Crawford, J.M., Townsend, C.A.† 2013. Combinatorial Domain Swaps Provide Insights into the Rules of Fungal Polyketide Synthase Programming and the Rational Synthesis of Non-Native Aromatic Products. Angew. Chem. Int. Ed.52(6): 1718-21. 

21. Somvanshi, V.S., Sloup, R.E., Crawford, J.M., Martin, A.R., Heidt, A.J., Kim, K.-S., Clardy, J., Ciche, T.A.† 2012. A Single Promoter Inversion Switches Photorhabdus Between Pathogenic and Mutualistic States. Science. 337: 88-93. 

     Research Highlights: David, R. 2012. Bacterial pathogenesis: The two faces of P. luminescens. Nature Rev. Micro. 10 (9): 594. News: Yong, E. 2012. Worm kills insects by vomiting Hulk-like bacteria. Discover. July 5. News: Noonan, T. 2012. Gene switch that turns bacteria into mighty Hulk. NewScientist. July. News: Cameron, L. 2012. Jekyll and Hyde bacteria aids or kills, depending on chance. Michigan State University News and in ScienceDaily. July 5.

20. Crawford, J.M.*, Portmann, C.*, Zhang, X., Roeffaers, M.B.J., and Clardy, J.† 2012. Small molecule perimeter defense in entomopathogenic bacteria. Proc. Natl. Acad. Sci. USA. 109 (27): 10821-10826. 

     Nature Research Highlights: 2012. Microbiology: Bacterial border defence. Nature. 486: 297.

19. Crawford, J.M. and Clardy, J.† 2012. Microbial genome mining answers longstanding biosynthetic questions. Proc. Natl. Acad. Sci. USA. 109 (20): 7589-90. 

18. Crawford, J.M., Portmann, C., Kontnik, R. Walsh, C.T., and Clardy, J.† 2011. NRPS substrate promiscuity diversifies the xenematides. Org. Lett. 13 (19): 5144-5147. 

17. Crawford, J.M.*, Mahlstedt, S.A.*, Malcolmson, S.J., Clardy, J., and Walsh, C.T.† 2011. Dihydrophenylalanine: A prephenate-derived Photorhabdus luminescens antibiotic and intermediate in dihydrostilbene biosynthesis. Chem. Biol. 18: 1102-1112. 

16. Crawford, J.M. and Clardy, J.† 2011. Bacterial symbionts and natural products. Chem. Commun. 47: 7559-7566.

15. Crawford, J.M. and Townsend, C.A.† 2010. New insights into the formation of fungal aromatic polyketides. Nature Rev. Micro. 8 (12): 879-889. 

14. Crawford, J.M. and Clardy, J.† 2010. Biosynthesis: Not just passing through. Nature Chem.2: 805-807.

13. Kontnik, R.*, Crawford, J.M.*, and Clardy, J.† 2010. Exploiting a global regulator for small molecule discovery in Photorhabdus luminescens. ACS Chem. Biol. 5 (7): 659-665. [selected for cover; Maximizing Metabolites] 

     2010. Introducing Our Authors. ACS Chem. Biol. 5 (7): 626-627.

12. D’Onofrio, A.*, Crawford, J.M.*, Stewart, E.J., Witt, K. Gavrish, E. Epstein, S., Clardy, J.†, and Lewis, K.† 2010. Siderophores from neighboring organisms promote the growth of uncultured bacteria. Chem. Biol. 17: 254-264. [selected for cover; Culturing the Uncultured]

     The Loom: Zimmer, Carl. 2010. Luring out the missing biosphere. Discover. March 26. Hidden Jewels: Schipani, V. 2010. Bacteria need friendly neighbors. Top 7 Hidden Jewels (#2), Faculty of 1000. October 26. Feature: Potera, C. 2010. Siderophores shed light on the “great plate count anomaly.” Microbe. Feature and podcast. August. ASM Blog: Lewis, K. Small things considered: The uncultured bacteria. The Microbe Blog. July 12.

11. Ehrlich, K.C.*†, Chang, P.-K.*, Scharfenstein, L., Cary, J.W., Crawford, J.M., and Townsend, C.A. 2010. Absence of the aflatoxin biosynthesis gene, norA, allows accumulation of deoxyaflatoxin B1 in Aspergillus flavus cultures. FEMS Microbiol. Lett. 305: 65-70. 

10. Korman, T.P.*, Crawford, J.M.*, Labonte, J., Wong, J. Townsend, C.A.†, and Tsai, S.-C.† 2010. Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis. Proc. Natl. Acad. Sci. USA. 107: 6246-6251.

9. Crawford, J.M.*, Kontnik, R.*, and Clardy, J.† 2010. Regulating alternative lifestyles in entomopathogenic bacteria. Current Biology. 20: 69-74. [selected for cover; Signaling in a Trilateral Symbiosis]

     Dispatch: Waterfield, N. 2010. Host-pathogen interactions: Proline gives insect pathogens the green light. Current Biology. 20: R13-15. Focus: Garces, R. and Neal, R. 2010. Jekyll-and-Hyde switch may turn off infection. Harvard Focus. February 5.  Crimson News: Stone, J.L. 2010. Roundworm bacteria research shows promise for development of new antibiotics. The Harvard Crimson. February 19. Editor’s Choice: Gough, N.R. 2010. Host-pathogen interactions: Proline promotes virulence. Sci. Signal. 3(106): ec31.

8. Crawford, J.M*, Korman, T.P.*, Labonte, J.W., Vagstad, A.L., Hill, E.A., Kamari-Bidkorpeh, O., Tsai, S.-C.†, and Townsend, C.A.† 2009. Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization. Nature. 461: 1139-1143.

     News & Views: Sherman, D.H. Enzyme’s black box cracked open. 2009. Nature. 461: 1068-1069. Research Highlights: Molloy, S. Fungal metabolism: Completing the circle. 2009. Nature Rev. Micro. 7: 842. Highlight: Weissman, K.J. Peering into the black box of fungal polyketide biosynthesis. 2010. ChemBioChem. 11: 485-488. Science Highlights: Hanna, R. Deadly carcinogen unraveled: the molecular origami of fungal polyketides. 2010. SSRL Science Highlights. March 31.

7. Belecki, K., Crawford, J.M., and Townsend, C.A.† 2009. Production of octaketide polyenes by the calicheamicin polyketide synthase CalE8: implications for the biosynthesis of enediyne core structures. J. Am. Chem. Soc. 131: 12564-12566.

6. Crawford, J.M., Vagstad, A.L., Ehrlich, K.C., Udwary, D.W., and Townsend, C.A.† 2008. Acyl-carrier protein - phosphopantetheinyltransferase partnerships in fungal fatty acid synthases. ChemBioChem. 9: 1559-1563.

5. Crawford, J.M., Vagstad, A.L., Ehrlich, K.C., and Townsend, C.A.† 2008. Starter unit specificity directs genome mining of polyketide synthase pathways in fungi. Bioorg. Chem. 36: 16-22.4.

4. Crawford, J.M., Vagstad, A.L., Whitworth, K.P., Ehrlich, K.C., and Townsend, C.A.† 2008. Synthetic strategy of nonreducing iterative polyketide synthases and the origin of the classical “starter unit effect.” ChemBioChem. 9: 1019-1023.

3. Crawford, J.M., Thomas, P.M., Scheerer, J.R. Vagstad, A.L., Kelleher, N.L.†, and Townsend, C.A.† 2008. Deconstruction of iterative multidomain polyketide synthase function. Science. 320: 243-246.

     Perspective: Weissman, K.J. Anatomy of a fungal polyketide synthase. 2008. Science. 320:186-187. Research Highlights: Smallridge, R. Fungal metabolism: Dissecting catalysis.2008. Nature Rev. Micro. 6: 414-415. Concentrates: Fungal enzyme deconstructed. Chemical & Engineering News. 2008. 86: 50-51.

2. Townsend, C.A.†, Crawford, J.M., and Bililign, T. 2006. New images evoke FAScinating questions. Chem. Biol. 4: 349-351.

1. Crawford, J.M., Dancy, B.C.E., Hill, E.A., Udwary, D.W., and Townsend, C.A.† 2006. Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase. Proc. Natl. Acad. Sci. USA. 103: 16728-16733.